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    Fahrplanauskunft der Haltestelle bzw. Bahnhof Borisow in Barysaŭ. 6. Okt. Der frühere Regierungschef Bojko Borisow hat zwar die Wahlen gewonnen. Doch erweist sich die Regierungsbildung als schwierig. Bulgarien. in der Berezina glücklich entdeckte Fuhrt, 2 Meilen oberhalb Borisow, auf das linke Ufer entkommen waren, – ein Umstand, der kurz darauf von größter.

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    This article is protected by copyright. Women with multiple sclerosis MS experience an elevated risk of relapse after giving birth.

    The effect of exclusive breastfeeding on postpartum risk of MS relapse is unclear. To determine the effect of exclusive breastfeeding on postpartum risk of MS relapse and to investigate the effect of introducing supplemental feedings on that risk.

    Data on pregnant women with relapsing-remitting MS were collected prospectively from January 1, , to June 30, , with 1 year follow-up post partum in the nationwide German MS and pregnancy registry.

    The effect of the intention to breastfeed exclusively no regular replacement of breastfeeding meals with supplemental feedings for at least 2 months compared with nonexclusive breastfeeding partial or no breastfeeding on the first postpartum MS relapse, using Cox proportional hazards regression model adjusted for age and disease activity, before and during pregnancy was analyzed.

    Data analysis was performed from August 30, , to May 25, Exclusive breastfeeding defined as at least 2 months of breastfeeding without regular replacement of any meal by supplemental feeding.

    First postpartum MS relapse. Of women, The findings of this study suggest that exclusive breastfeeding is a modestly effective MS treatment with a natural end date.

    Our study provides further evidence that women with MS who breastfeed exclusively should be supported to do so since it does not increase the risk of postpartum relapse.

    Distinct functionality of neutrophils in Multiple Sclerosis and Neuromyelitis Optica. In contrast to multiple sclerosis MS , lesions in neuromyelitis optica NMO frequently contain neutrophils.

    However, the phenotypic profile of neutrophils in these two distinct pathologies remains unknown. However, contrary to MS neutrophils, NMO neutrophils show reduced adhesion and migratory capacity as well as decreased reduced production of reactive oxygen species respiratory burst and degranulation.

    Neutrophil profile in multiple sclerosis and neuromyelitis optica. Optimal management of multiple sclerosis during pregnancy: Multiple sclerosis MS is a common inflammatory demyelinating disorder of the central nervous system.

    It frequently affects females in their reproductive phase of life. Therefore, family planning, pregnancy, and breastfeeding are important issues in the management of MS, particularly with respect to counseling and drug treatment.

    This paper reviews currently available data on the outcome of pregnancies in MS patients and the influence of pregnancy on the course of the disease.

    We give an update on the use of various disease-modifying MS drugs during pregnancy and breastfeeding. Pregnancy in Multiple Sclerosis: Background Multiple sclerosis MS preferentially affects females at childbearing age.

    For this reason patients and treating physicians were frequently confronted with questions concerning family planning, pregnancy and birth. Objective The aim of this study was to evaluate the expertise about pregnancy related topics in multiple sclerosis of neurologists in private practice.

    Methods We developed a survey with 16 multiple choice questions about pregnancy related topics and sent it to neurologists in private practice in Berlin, Germany.

    Results 56 completed questionnaires were sent back. Conclusion To provide a comprehensive counseling, MS patients with desire for children should be counseled by physicians with a lot of experience in MS treatment.

    Update on the diagnosis and treatment of neuromyelitis optica: Neuromyelitis optica NMO, Devic's syn-drome , long considered a clinical variant of multiple sclerosis, is now regarded as a distinct disease entity.

    In addition, imaging techniques, particularly magnetic reso-nance imaging of the brain and spinal cord, are obligatory in the diagnostic workup.

    Other imaging modalities such as optical coherence tomography are proposed as useful tools in the assessment of retinal damage.

    Therapy of NMO should be initiated early. Azathioprine and rituximab are suggested as first-line treatments, the latter being increasingly regarded as an established therapy with long-term efficacy and an acceptable safety profile in NMO patients.

    Neuromyelitis optica NMO, Devic's syndrome , long considered a clinical variant of multiple sclerosis, is now regarded as a distinct disease entity.

    Other immu-nosuppressive drugs, such as methotrexate, mycophenolate mofetil and mitoxantrone, are recommended as second-line treatments.

    Visual evoked potentials in neuromyelitis optica and its spectrum disorders. We found reduced amplitudes in only Delayed P latencies in eyes without prior ON suggested this was a subclinical affection.

    The data indicate heterogenous patterns in NMO, warranting further investigation. Optical coherence tomography OCT studies investigating retinal changes in both diseases focused primarily on the retinal nerve fiber layer RNFL while rare data are available on deeper intra-retinal layers.

    Semi-automatic intra-retinal layer segmentation was used to quantify intra-retinal layer thicknesses. In a subgroup low contrast visual acuity LCVA was assessed.

    However, OCT is still insufficient to help with the clinically relevant differentiation of both conditions in an individual patient.

    Autoantibodies to neuronal tissue are becoming increasingly more important in the evaluation and classification of several neurological diseases, e. As these disorders are rare, no evidence-based recommendations for therapy are available.

    Currently, immunomodulating or immunosuppressive drugs are administered in most cases. In paraneoplastic syndromes treatment of the underlying cancer is of considerable importance.

    This overview summarizes current experiences and recommendations in the treatment of autoimmune neurological disorders. Therapieoptionen bei immunvermittelten Enzephalomyelitiden.

    Autoantikörper gegen neuronale Strukturen gewinnen in der Differenzialdiagnostik und Klassifikation verschiedener neurologischer Erkrankungen zunehmend an Bedeutung, z.

    Da es sich um seltene Syndrome handelt, liegen bislang keine ausreichend evidenzbasierten Therapiedaten vor. Zum aktuellen Zeitpunkt werden vorrangig verschiedene immunmodulatorische und -suppressive Substanzen angewendet, zusätzlich spielt bei paraneoplastischen Syndromen die Behandlung der zugrunde liegenden Krebserkrankung eine zentrale Rolle.

    Diese Übersicht dient der zusammenfassenden Darstellung der aktuellen Literatur hinsichtlich bisheriger Erfahrungen in der Behandlung und daraus abgeleiteten Therapieempfehlungen.

    Concomitant amyotrophic lateral sclerosis and paraclinical laboratory features of multiple sclerosis: Coincidence or causal relationship?

    We report a year-old patient, presenting with paresis, muscle atrophy and dysarthria, all symptoms accordable to definite amyotrophic lateral sclerosis ALS.

    On the basis of this case report, we discuss possible overlaps between both diseases by comparing clinical and paraclinical features including laboratory, radiological and electrophysiological diagnostics.

    As genetic, as well as environmental, factors are assumed to be involved in the development of both the diseases, literature is reviewed according to similar cases, results of autopsies and possible parallels in pathogenesis.

    In summary, based on the data currently available, the hypothesis of ALS being a neurodegenerative multisystem disorder, a common pathophysiological pathway or, alternatively, a random comorbidity of ALS and MS in this patient has to be discussed.

    Expert recommendations to personalization of medical approaches in treatment of multiple sclerosis: Multiple sclerosis is the most common chronic autoimmune disease of the central nervous system which preferentially affects females at childbearing age.

    For this reason, patients and treating physicians were frequently confronted with questions concerning family planning, pregnancy and birth.

    Preventive and personalized treatment approaches are considered, because topics as heredity, risk of congenital malformations, influence of pregnancy on MS and aspects of drug therapy during the period of conception, pregnancy, puerperium and lactation have to be discussed.

    Here, we provide an overview about the current state of knowledge regarding these issues. Diagnosis and treatment of neuromyelitis optica.

    Consensus recommendations of the Neuromyelitis Optica Study Group. Sep Jahrestagung der Deutschen Gesellschaft für Neurologie.

    Dabei sind Kachexie, Ophtalmoplegie und autonome Störungen etabliert. Nach 78, 33 und 31 Monaten Erkrankungsdauer trat eine bilaterale Hörminderung auf.

    In zwei Fällen 1u. Klinisch und pathoanatomisch erfolgte der Ausschluss einer strukturellen Läsion des Mittelohrs.

    Bei einem dritten Patienten 3 konnte eine Schallleitungsstörung des Mittelohrs durch einen Serotympanum identifiziert werden.

    Nach Ausschluss anderer, symptomatischer Ursachen ist ein neurodegenerativer Prozess zu diskutieren. Davon abzugrenzen ist die Schallleitungsstörung, deren mögliche Ursache eine Bulbärsymptomatik mit Paresen der Musculi tensor veli palatini et levator palatini ist.

    Dabei kommt es zu Störungen der Belüftung und des Druckausgleichs des Mittelohrs mit resultierendem Serotympanum.

    Bei insgesamt steigender Beatmungsprävalenz erlangen atypische Symptome eine erhöhte Bedeutung. Amyotrophe Lateralsklerose mit primär progressiver Aphasie: Implikationen für das Patientenmanagement anhand eines Fallberichtes.

    Amyotrophe Lateralsklerose-Functional Rating Scale-online. Das Hosting und die Administration der Datenbank finden uber ein Servercluster mit redundantem Datastorage durch Servervirtualisierung statt.

    Die Selbstbewertung wird dem jeweiligen Patienten nach Authentifizierung als sessionsabhangige Jobqueue verfugbar gemacht Befragung 1 x Woche.

    Die Ergebnisse der Selbstbewertung werden lokal gespeichert, prozessiert und fur den Patienten graphisch visualisiert.

    In einem Beobachtungszeitraum von 18 Monaten wurden bei Patienten Visiten uber die Plattform durchgefuhrt. Die mittlere Dauer der Selbstbewertung betragt 12min und kann vom Patienten selbststandig durchgefuhrt werden.

    Die Praktikabilitat eines webbasierten Bewertungsscores in einem ambulanten Behandlungspfad ist damit gesichert. Die Behandlungseffizienz kann durch Verkurzung der Reaktionszeiten und Visualisierung von Krankheitstrends gesteigert werden.

    Gegenuber der herkommlichen Form der Datenerhebung ist eine zwolffach gesteigerte Datendichte erzielt worden, die den Krankheitsverlauf maximal objektiviert und zu einer erhohten Datenqualitat fuhrt.

    Elektive Termination der Beatmungstherapie bei der amyotrophen Lateralsklerose. Background Due to the growing use of artificial respiration in amyotrophic lateral sclerosis ALS , physicians are increasingly confronted with patients seeking discontinuation of therapy.

    Yet there are few systematic investigations of the withdrawal of ventilation therapy. The terminal phase after removing the mask was protracted The terminal phase in deep sedation was short 15—80 min.

    Conclusion The elective termination of ventilation requires differentiated pharmacologic palliative care.

    More controlled studies are required in order to establish evidence-based guidelines for the termination of ventilation.

    Due to the growing use of artificial respiration in amyotrophic lateral sclerosis ALS , physicians are increasingly confronted with patients seeking discontinuation of therapy.

    The terminal phase in deep sedation was short min. The elective termination of ventilation requires differentiated pharmacologic palliative care.

    Thalidomide causes sinus bradycardia in ALS. Neuroinflammation contributes to motor neuron degeneration in ALS. Thalidomide was therefore suggested as atherapeutic intervention for the treatment of ALS.

    We conducted a pilot, randomized clinical trial of THL in patients with ALS to assess safety, feasibility, and preliminary estimates of treatment efficacy.

    THL was initiated at mg per day for 6 weeks. Thereafter, the dose was increased every week by 50 mg until reaching the dose of mg per day and planned to continue for another 12 weeks.

    Mean heart rate dropped by 17 bpm with THL treatment. Severe symptomatic bradycardia of 30 bpm occurred in one patient.

    A further patient died from sudden unexpected death. The study was terminated prematurely for safety concerns. The secondary outcome variables showed similar results for both groups.

    It is conceivable, however, that the unexpected frequency and severity of THL-induced bradycardia may be related to subclinical involvement of the autonomic nervous system in ALS.

    A rarely diagnosed variant of amyotrophic lateral sclerosis]. Progressive muscle atrophy PMA is a degenerative disease of the lower motor neuron.

    The course of the illness and the fatal prognosis correspond to those of amyotrophic lateral sclerosis ALS. Neuropathologic and genetic findings support categorizing PMA within the spectrum of ALS, even though no clinical sign of a disorder of the upper motor neuron is demonstrable.

    The diagnosis of PMA is based on advanced extremity pareses and atrophies with a high progression rate. Respiratory insufficiency is determinative of the prognosis.

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    Flags indicate national team as defined under FIFA eligibility rules. Players may hold more than one non-FIFA nationality.

    Had international caps for their respective countries. Players whose name is listed in bold represented their countries while playing for BATE.

    From Wikipedia, the free encyclopedia. For other uses, see Bate. Borisov Arena Barysaw , Belarus. Archived from the original on 22 February Retrieved 8 February Archived from the original on 28 August To re-evaluate the utility of cerebrospinal fluid CSF analysis in the context of the revised McDonald criteria from , we conducted a retrospective multicenter study aimed at determining the prevalence and predictive value of oligoclonal IgG bands OCBs in patients with CIS.

    Patients were recruited from ten specialized MS centers in Germany and Austria. CSF analysis definitely helps to evaluate the prognosis in patients who do not have MS according to the revised McDonald criteria.

    Influence of female sex and fertile age on neuromyelitis optica spectrum disorders. Gender and age at onset are important epidemiological factors influencing prevalence, clinical presentation, and treatment response in autoimmune diseases.

    To evaluate the impact of female sex and fertile age on aquaporinantibody AQP4-ab status, attack localization, and response to attack treatment in patients with neuromyelitis optica NMO and its spectrum disorders neuromyelitis optica spectrum disorder NMOSD.

    Female-to-male ratios, diagnosis at last visit NMO vs NMOSD , attack localization, attack treatment, and outcome were compared according to sex and age at disease or attack onset.

    In AQP4-ab-positive patients, female predominance was most pronounced during fertile age female-to-male ratio Epidemiology, clinical presentation, radiological and laboratory features, treatment responses, and long-term outcome.

    The sex ratio was 1: Median age at onset was 31 years range Perioptic enhancement was present in several patients. Fourty-one percent had a history of simultaneous ON and myelitis.

    Intravenous methylprednisolone IVMP and long-term immunosuppression were often effective; however, treatment failure leading to rapid accumulation of disability was noted in many patients as well as flare-ups after steroid withdrawal.

    Full recovery was achieved by plasma exchange in some cases, including after IVMP failure. Breakthrough attacks under azathioprine were linked to the drug-specific latency period and a lack of cotreatment with oral steroids.

    Interferon-beta was associated with ongoing or increasing disease activity. Rituximab and ofatumumab were effective in some patients.

    However, treatment with rituximab was followed by early relapses in several cases; end-of-dose relapses occurred months after the first infusion.

    Frequency, syndrome specificity, influence of disease activity, long-term course, association with AQP4-IgG, and origin. Antibodies to myelin oligodendrocyte glycoprotein MOG-IgG have been suggested to play a role in a subset of patients with neuromyelitis optica and related disorders.

    MOG-IgG was present already at disease onset. Serum titers depend on disease activity and treatment status.

    To assess volumes and microstructural integrity of deep gray matter structures in a homogeneous cohort of patients with neuromyelitis optica spectrum disorder NMOSD.

    Volumetry of deep gray matter structures DGM; thalamus, caudate, putamen, globus pallidus, hippocampus, amygdala, nucleus accumbens was performed using 2 independent automated methods.

    Microstructural integrity was assessed based on diffusion tensor imaging. Both volumetric analysis methods consistently revealed similar volumes of DGM structures in patients and controls without significant group differences.

    Moreover, no differences in DGM microstructural integrity were observed between groups. NMOSD imaging studies should be interpreted with respect to Ab status, educational background, and ethnicity of included patients.

    Evaluation of attacks and treatment courses. Neuromyelitis optica NMO attacks are often severe, difficult to treat, and leave residual deficits.

    Here, we analyzed the frequency, sequence, and efficacy of therapies used for NMO attacks. Remission status was analyzed with generalized estimating equations GEE , a patient-based statistical approach.

    The first treatment course led to CR in Second, third, fourth, and fifth treatment courses were given in Remission rates were higher for isolated optic neuritis vs.

    Particularly myelitis and bilateral ON have poor remission rates. Escalation of attack therapy improves outcome. This article is protected by copyright.

    Women with multiple sclerosis MS experience an elevated risk of relapse after giving birth. The effect of exclusive breastfeeding on postpartum risk of MS relapse is unclear.

    To determine the effect of exclusive breastfeeding on postpartum risk of MS relapse and to investigate the effect of introducing supplemental feedings on that risk.

    Data on pregnant women with relapsing-remitting MS were collected prospectively from January 1, , to June 30, , with 1 year follow-up post partum in the nationwide German MS and pregnancy registry.

    The effect of the intention to breastfeed exclusively no regular replacement of breastfeeding meals with supplemental feedings for at least 2 months compared with nonexclusive breastfeeding partial or no breastfeeding on the first postpartum MS relapse, using Cox proportional hazards regression model adjusted for age and disease activity, before and during pregnancy was analyzed.

    Data analysis was performed from August 30, , to May 25, Exclusive breastfeeding defined as at least 2 months of breastfeeding without regular replacement of any meal by supplemental feeding.

    First postpartum MS relapse. Of women, The findings of this study suggest that exclusive breastfeeding is a modestly effective MS treatment with a natural end date.

    Our study provides further evidence that women with MS who breastfeed exclusively should be supported to do so since it does not increase the risk of postpartum relapse.

    Distinct functionality of neutrophils in Multiple Sclerosis and Neuromyelitis Optica. In contrast to multiple sclerosis MS , lesions in neuromyelitis optica NMO frequently contain neutrophils.

    However, the phenotypic profile of neutrophils in these two distinct pathologies remains unknown. However, contrary to MS neutrophils, NMO neutrophils show reduced adhesion and migratory capacity as well as decreased reduced production of reactive oxygen species respiratory burst and degranulation.

    Neutrophil profile in multiple sclerosis and neuromyelitis optica. Optimal management of multiple sclerosis during pregnancy: Multiple sclerosis MS is a common inflammatory demyelinating disorder of the central nervous system.

    It frequently affects females in their reproductive phase of life. Therefore, family planning, pregnancy, and breastfeeding are important issues in the management of MS, particularly with respect to counseling and drug treatment.

    This paper reviews currently available data on the outcome of pregnancies in MS patients and the influence of pregnancy on the course of the disease.

    We give an update on the use of various disease-modifying MS drugs during pregnancy and breastfeeding. Pregnancy in Multiple Sclerosis: Background Multiple sclerosis MS preferentially affects females at childbearing age.

    For this reason patients and treating physicians were frequently confronted with questions concerning family planning, pregnancy and birth.

    Objective The aim of this study was to evaluate the expertise about pregnancy related topics in multiple sclerosis of neurologists in private practice.

    Methods We developed a survey with 16 multiple choice questions about pregnancy related topics and sent it to neurologists in private practice in Berlin, Germany.

    Results 56 completed questionnaires were sent back. Conclusion To provide a comprehensive counseling, MS patients with desire for children should be counseled by physicians with a lot of experience in MS treatment.

    Update on the diagnosis and treatment of neuromyelitis optica: Neuromyelitis optica NMO, Devic's syn-drome , long considered a clinical variant of multiple sclerosis, is now regarded as a distinct disease entity.

    In addition, imaging techniques, particularly magnetic reso-nance imaging of the brain and spinal cord, are obligatory in the diagnostic workup.

    Other imaging modalities such as optical coherence tomography are proposed as useful tools in the assessment of retinal damage. Therapy of NMO should be initiated early.

    Azathioprine and rituximab are suggested as first-line treatments, the latter being increasingly regarded as an established therapy with long-term efficacy and an acceptable safety profile in NMO patients.

    Neuromyelitis optica NMO, Devic's syndrome , long considered a clinical variant of multiple sclerosis, is now regarded as a distinct disease entity.

    Other immu-nosuppressive drugs, such as methotrexate, mycophenolate mofetil and mitoxantrone, are recommended as second-line treatments. Visual evoked potentials in neuromyelitis optica and its spectrum disorders.

    We found reduced amplitudes in only

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